2-Nitrophenol → 2-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)nitrobenzene

HRID 845000Notes

Reaction equation

HRID 845000 reaction equation
[Cl:1][C:2]1[C:3](F)=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1.[N+:13]([C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[OH:22])([O-:15])=[O:14]>>[Cl:1][C:2]1[C:3]([O:22][C:17]2[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=2[N+:13]([O-:15])=[O:14])=[N:4][CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:7]=1

Participants

3

Reactant 2

HCID 69472-NitrophenolHCID 12680753-Chloro-2-fluoro-5-(trifluoromethyl)pyridine

Product 1

HCID 150175302-(3-Chloro-5-trifluoromethyl-2-pyridyloxy)nitrobenzeneYield 63%

Procedure

This material was prepared in 63% yield from 3-chloro-2-fluoro-5-trifluoromethylpyridine and 2-nitrophenol following the general procedure outlined in Example 88. The product was isolated as an amber oil which was characterized by IR and 1H NMR spectroscopy.

Workup

  1. customThe product was isolated as an amber oil which

Sources & evidence

ORD record
ord-121d57b3b16f4f9eaa30c52f00df4893
Source dataset
uspto-grants-1988_07
Patent number
US04755212

Reaction notes

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