HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ammonia → HCID 70419709, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ammonia | HCID 222 | — |
| Reactant | Phosphorus oxychloride | HCID 24813 | — |
| Reactant | HCID 70418736 | HCID 70418736 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 70419709 | HCID 70419709 | — |
Reaction Steps
A solution of 29.5 g. trans-2-fluoro-4-(5-pentyl-1,4-dioxan-2-yl)-benzamide (obtainable from the acid chloride and NH3) in 500 ml. DMF is mixed dropwise at 50°, while stirring, with 65 g. POCl3. After a further one hour stirring, one pours on to ice, works up as usual and obtains trans-2-fluoro-4-(5-pentyl-1,4-dioxan-2-yl)-benzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04755323 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-0b6e460dde3a47d8b5804c53e1f5c91b |
| Source note | uspto-grants-1988_07 |