HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 845025Generated: October 31, 2026
Acetic Anhydride → Ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate
https://huagongshe.com/reaction/845025
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetic Anhydride | HCID 7918 | — |
| Reactant | Ethyl 3-oxo-(2,3,4,5-tetrafluorophenyl)propanoate | HCID 600916 | — |
| Reactant | Ethylorthoformate | HCID 53630039 | — |
| Product | Ethyl 3-ethoxy-2-(2,3,4,5-tetrafluorobenzoyl)acrylate | HCID 54346083 | 94.3% |
Reaction Steps
A mixture of ethyl α-(2,3,4,5-tetrafluorobenzoyl)acetate (0.7 g), ethyl orthoformate (0.67 g) and acetic anhydride (0.74 g) is heated at 150° C. for 1.5 hour. After the reaction, the volatile material is distilled off at 120° C. under reduced pressure with a water pump to give ethyl 2-(2,3,4,5-tetrafluorobenzoyl)-3-ethoxyacrylate (0.8 g) as a mixture of cis and trans isomers.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04755513 |
|---|
| Source dataset | uspto-grants-1988_07 |
|---|
| ORD ID | ord-fbe29bd3fc2c44abb97dd4a511f57025 |
|---|
| Source note | uspto-grants-1988_07 |
|---|
