Potassium Acetate → Methyl 2-(3-(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-8-yl)phenyl)acetate

Participants

Role	Name	HCID	Charge
Reactant	Potassium Acetate	HCID 517044	—
Reactant	3-(2-Methoxy-2-oxoethyl)phenylboronic acid, pinacol ester	HCID 11097791	—
Reactant	8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide	HCID 44242427	—
Catalyst	Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)	HCID 178418228	—
Solvent	Dimethyl Sulfoxide	HCID 679	—
Solvent	Acetonitrile	HCID 6342	—
Product	Methyl 2-(3-(2-((2-chlorophenyl)(methyl)carbamoyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-8-yl)phenyl)acetate	HCID 44241821	—

Reaction Conditions

Temperature	80 °C

Reaction Steps

Following the procedure of Example 93, 8-bromo-N-(2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide 150, methyl 2-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetate, potassium acetate, and Pd(dppf)Cl2 in acetonitrile and DMSO were heated at 80° C. overnight to give 200. MS: (ESI+) 518.2

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08846762B2
Source dataset	uspto-grants-2014_09
ORD ID	ord-e68af114d83347c78e7a8d2195b9a385
Source note	uspto-grants-2014_09