Ethyl Thioglycolate → HCID 86742259, compound

Participants

Reaction Steps

A solution of 50 g of 3-nitro-2-chloropyridine and 38 g of ethyl mercaptoacetate in 400 ml of ethanol containing 30 g of sodium bicarbonate is heated under reflux for 7 hours. The solution is subsequently concentrated in vacuo and then, after cooling, the residue is treated with water and ice and extracted with ether. The ether phase is washed with water and dried, the solvent is evaporated off and a residue is recovered which crystallizes from isopropyl ether. The crystals are filtered off and dried to give 49 g of ethyl 3-nitropyridine-2-mercaptoacetate in the form of crystals of melting point 58° C.

Provenance & Evidence