Pyridine → 10-Propionyl dithranol

Participants

Reaction Conditions

Reaction Steps

To a suspension of 56.6 g (0.25 mole) of purified anthralin in 1750 cm3 of anhydrous toluene, there are added at ambient temperature 27.3 cm3 of anhydrous pyridine (0.34 mole) and then, slowly, over about a 20 minute period, 26.2 cm3 of propionyl chloride (0.3 mole) are added. The mixture is then heated to 85° C. for about 1 hour. After return to ambient temperature, there are added to the reaction mixture 27.3 cm3 of pyridine and 26.2 cm3 of propionyl chloride. This mixture is then heated for 1 hour at a temperature of about 85° C.

Provenance & Evidence