反应详情

A mixture of 6-chloropurine riboside (8.61 g, 30 mmol), (1-phenylcyclopropyl)methylamine (4.41 g, 30 mmol) and triethylamine (6.06 g, 60 mmol) are refluxed in stirring ethanol (300 mL) under N2 for 20 h. On cooling to 0° the product crystallized. Vacuum filtration and drying in vacuo gives N6-((1-phenylcyclopropyl)methyl)adenosine (9.24 g, 79%) as a very pale khaki solid m.p. 118°-23° C. Found: C, 59.58; H, 5.77; N, 17.49%. C20H23N5O4 calculated requires: C, 60.45; H, 5.79; N, 17.63%.

1. temperatureare refluxed
2. temperatureOn cooling to 0° the product
3. customcrystallized
4. filtrationVacuum filtration
5. customdrying in vacuo