Triethylamine → HCID 15611191、化合物

HRID 845112ノート

反応式

HRID 845112 の反応式
[CH:1]1[N:6]=[C:5](Cl)[C:4]2[N:8]=[CH:9][N:10]([C@@H:11]3[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]3[OH:19])[C:3]=2[N:2]=1.[C:20]1([C:26]2([CH2:29][NH2:30])[CH2:28][CH2:27]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(N(CC)CC)C>C(O)C>[C:20]1([C:26]2([CH2:29][NH:30][C:5]3[C:4]4[N:8]=[CH:9][N:10]([C:3]=4[N:2]=[CH:1][N:6]=3)[C@@H:11]3[O:15][C@H:14]([CH2:16][OH:17])[C@@H:13]([OH:18])[C@H:12]3[OH:19])[CH2:27][CH2:28]2)[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

参加物

5

反応物 3

HCID 8471TriethylamineHCID 702871-PhenylcyclopropanemethanamineHCID 930036-Chloropurine riboside

生成物 1

HCID 15611191HCID 15611191、化合物収率 79%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

A mixture of 6-chloropurine riboside (8.61 g, 30 mmol), (1-phenylcyclopropyl)methylamine (4.41 g, 30 mmol) and triethylamine (6.06 g, 60 mmol) are refluxed in stirring ethanol (300 mL) under N2 for 20 h. On cooling to 0° the product crystallized. Vacuum filtration and drying in vacuo gives N6-((1-phenylcyclopropyl)methyl)adenosine (9.24 g, 79%) as a very pale khaki solid m.p. 118°-23° C. Found: C, 59.58; H, 5.77; N, 17.49%. C20H23N5O4 calculated requires: C, 60.45; H, 5.79; N, 17.63%.

後処理

  1. temperatureare refluxed
  2. temperatureOn cooling to 0° the product
  3. customcrystallized
  4. filtrationVacuum filtration
  5. customdrying in vacuo

出典と根拠

ORDレコード
ord-7a022ce9ea4e439d8f387823892afc08
出典データセット
uspto-grants-1988_07
特許番号
US04755594

反応ノート

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