Triethylamine → HCID 15611195, compound

Participants

Reaction Steps

Reaction of the above amine (1.53 g, 10 mmol) with 6-chloropurine riboside (2.87 g, 10 mmol) and triethylamine (2.02 g, 20 mmol) as described in Example 1 gives, after a second crystallization from ethanol, N6((1-thien-2-ylcyclopropyl)methyl)adenosine (2.90 g, 71%) as a fluffy off-white solid m.p. 136°-138.5° C. Found: C, 53.78; H, 5.45; N, 17.28; S, 7.52%. C18H21N5O4S calculated requires: C, 53.60; H, 5.21; N, 17.37; S, 7.94%.

Provenance & Evidence