Triethylamine → HCID 53971714, compound

Participants

Reaction Steps

(1-Thien-2-ylcyclopropyl)methylamine (0.55 g, 3.6 mmol), see Example 3, 6-chloropurine-5'-deoxy-5'-chlororiboside-2',3'-isopropylidene (1.25 g, 3.6 mmol, as prepared in Example 5) and triethylamine (0.75 g, 7.5 mmol) are reacted together as described in Example 5. Aqueous formic acid hydrolysis gives 5'-chloro-5'-deoxy-N6-((1-thien-2-ylcyclopropyl)methyl)adenosine (0.44 g, 29%) as a light khaki solid foam m.p. 69°-75° C. Found: C, 50.53; H, 4.90; N, 15.90; Cl, 9.13; S, 7.22%. C18H20ClN5O3S calculated requires: C, 51.25; H, 4.74; N, 16.61; Cl, 8.42; S, 7.59%.

Provenance & Evidence