6-Chloropurine riboside → HCID 15611201, compound

Participants

Reaction Steps

The above amine (1.67 g, 10 mmol) is reacted with 6-chloropurine riboside (2.87 g, 10 mmol) as described in Example 1 and 7 is purified by column chromatography to give N6-(1-(thien-2-ylcyclobutyl)methyl)adenosine (3.18 g, 76%) as a colorless glass m.p. 84°-92° C. Found: C, 54.88; H, 5.69; N, 16.77; S, 7.55%. C19H23N5O4S calculated requires: C, 54.68; H, 5.52; N, 16.79; S, 7.67%.

Provenance & Evidence