Triethylamine → N6-((1-(4-chlorophenyl)cyclopropyl)methyl)adenosine

Participants

Reaction Steps

Reaction of the above amine (1.48 g, 8 mmol) with 6-chloropurine riboside (2.09 g, 7.3 mmol) and triethylamine (1.1 mL, 8 mmol) as prepared in Example 1 and 7 gives N6-((1-(4-chlorophenyl)cyclopropyl)methyl)adenosine (1.47 g, 47%) as a cream colored solid m.p. 132°-8° C. Found: C, 56.16; H, 5.22; N, 15.54; Cl, 9.12%. C20H22N5O4Cl calculated requires: C, 55.62; H, 5.10; N, 16.22; Cl, 8.23%.

Provenance & Evidence