Dimethylamine → HCID 57900423, compound

HRID 84515Notes

Reaction equation

HRID 84515 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]([CH2:28][CH2:29][OH:30])[C:12]([C:14]1[S:27][C:17]2[C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[O:20][CH2:21][CH2:22][C:16]=2[CH:15]=1)=[O:13])[C:5](O)=[O:6].[CH3:31][NH:32][CH3:33]>>[Cl:1][C:2]1[CH:3]=[C:4]([C:5](=[O:6])[N:32]([CH3:33])[CH3:31])[CH:8]=[CH:9][C:10]=1[N:11]([CH2:28][CH2:29][OH:30])[C:12]([C:14]1[S:27][C:17]2[C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[O:20][CH2:21][CH2:22][C:16]=2[CH:15]=1)=[O:13]

Participants

3

Reactant 2

HCID 674DimethylamineHCID 579003303-chloro-4-(N-(2-hydroxyethyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid

Product 1

HCID 57900423HCID 57900423, compoundYield 50%

Procedure

Following the procedure of Example 91, 3-chloro-4-(N-(2-hydroxyethyl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid and dimethylamine were reacted to give 220 (yield 50%). MS: (ESI+) 471.1

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-22cb7ff6df224c15bfffa65909c5d9e8
Source dataset
uspto-grants-2014_09
Patent number
US08846762B2

Reaction notes

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