Sulfuric Acid → HCID 178517716, compound

HRID 845174Notes

Reaction equation

HRID 845174 reaction equation
N[C:2]1[C:7]([O:8][C:9]([F:17])([F:16])[CH:10]([F:15])[C:11]([F:14])([F:13])[F:12])=[CH:6][CH:5]=[CH:4][N:3]=1.S(=O)(=O)(O)[OH:19].N([O-])=O.[Na+]>O>[F:16][C:9]([F:17])([O:8][C:7]1[C:2]([OH:19])=[N:3][CH:4]=[CH:5][CH:6]=1)[CH:10]([F:15])[C:11]([F:14])([F:13])[F:12]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14740061HCID 14740061, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 178517716HCID 178517716, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

2.6 g (10 mmol) of 2-amino-3-(1,1,2,3,3,3-hexafluoro-1propyloxy)pyridine were diazotized at 0° C. in 35 ml of 2N sulfuric acid using 0.76 g (11 mmol) of sodium nitrite in 5 ml of water. The reaction mixture was stirred for 30 minutes and the product was extracted using ethyl acetate. The organic phase was washed until neutral, dried using MgSO4 and concentrated by evaporation.

Workup

  1. extractionthe product was extracted
  2. washThe organic phase was washed until neutral,
  3. customdried
  4. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-00efae6ed0b24ef785411a881cee0c30
Source dataset
uspto-grants-1988_07
Patent number
US04756739

Reaction notes

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