HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorodifluoromethane → 2,3-Dichloro-5-(difluoromethoxy)pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorodifluoromethane | HCID 6372 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | 2,3-Dichloro-5-hydroxypyridine | HCID 14391672 | — |
| Solvent | Water | HCID 962 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2,3-Dichloro-5-(difluoromethoxy)pyridine | HCID 14556197 | — |
Reaction Steps
Chlorodifluoromethane was passed at 50° C. into a mixture of 32.8 g (0.2 mol) of 5,6-dichloro-3-pyridinol in 200 ml of 1,4-dioxane and 40 g (1 mol) of sodium hydroxide in 100 ml of water until starting material was no longer present. The further procedure was then carried out as described in Example 1.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04756739 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-3076207293af4a759c59a9a9806766ae |
| Source note | uspto-grants-1988_07 |