Sulfuric Acid → HCID 178516284, compound

HRID 845177Notes

Reaction equation

HRID 845177 reaction equation
N([O-])=O.[Na+].N[C:6]1[CH:11]=[CH:10][C:9]([O:12][C:13]([F:18])([F:17])[CH:14]([F:16])[F:15])=[CH:8][N:7]=1.S(=O)(=O)(O)[OH:20]>O>[F:17][C:13]([F:18])([O:12][C:9]1[CH:10]=[CH:11][C:6]([OH:20])=[N:7][CH:8]=1)[CH:14]([F:16])[F:15]

Participants

5

Reactant 3

HCID 1118Sulfuric AcidHCID 14665030HCID 14665030, compoundHCID 23668193Sodium Nitrite

Product 1

HCID 178516284HCID 178516284, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

A solution of 10.3 g (149 mmol) of sodium nitrite in 16.5 ml of water was added dropwise with stirring to a solution of 23 g (109 mmol) of 2-amino-5-(1,1,2,2-tetrafluoroethoxy)pyridine in 103 ml of water and 21.9 g of concentrated sulfuric acid at 0° C. The mixture was stirred for 3 hours at 20°-25° C., and the colorless solid was filtered off under suction and washed with water until free of acid.

Workup

  1. filtrationthe colorless solid was filtered off under suction
  2. washwashed with water until free of acid

Sources & evidence

ORD record
ord-46d52081e0df49c2a008c86207e1fe60
Source dataset
uspto-grants-1988_07
Patent number
US04756739

Reaction notes

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