Acetic Acid → HCID 14208609, compound

Participants

Reaction Steps

A mixture of the product from Example 2 (0.30 g, 1.17 mole) and N-(4,6-dimethylpyrimidin-2-yl)phenyl carbamate (0.30 g, 1.23 mmole) in acetonitrile (30 mL) was treated with DBU (184 μl, 1.23 mmole) at room temperature overnight. The solution was poured into water and acidified with acetic acid. The solid which precipitated was collected on a glass funnel and washed with water, butylchloride, and ether to yield 0.15 g white solid; m.p. 190°-192° C.; NMR (CDCl3)δ: 2.0-2.2 (m, 2H), 2.3-2.5 (m, with s at δ2.44, 8H), 2.7-2.8 (m, 2H), 6.25 (s, 1H), 6.77 (s, 1H), 7.36 and 7.66 (AB q, J=5.4 Hz, 2H); IR cm-1 (nujol): 1730, 1700 (shoulder at 1685 and 1675), 1605, 1550, 1170, 1140.

Provenance & Evidence