HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 5-Bromomethyl-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | 5-Hydroxymethyl-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester | HCID 54493509 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-Bromomethyl-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester | HCID 54141050 | — |
Reaction Steps
5-Hydroxymethyl-4-methoxymethyl-beta-carboline-3-carboxylic acid isopropyl ester (1.0 g) is dissolved in dichloromethane. A solution of 0.83 phosphorous tribromide in 10 ml of dichloromethane is added. After 20 hours the resulting precipitate is suctioned off. The yield is 1.0 g of yellow crystals with indeterminate melting point.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04757070 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-75174e825b9f412a9c9e2fd33b67c449 |
| Source note | uspto-grants-1988_07 |