Benzoyl chloride → HCID 13032033, compound

Participants

Reaction Steps

To a solution of 1.00 g (8.55 mmol) of O-tetrahydropyran-2-ylhydroxylamine (prepared as described in U.S. Pat. No. 4,607,053, Example 2, Part A) and 1.4 ml (10 mmol) of sieve-dried triethylamine in 15 ml of dry CH2Cl2 cooled to -20 was added a solution of 1.50 g (10.7 mmol) of benzoyl chloride in 5 ml of CH2Cl2 over 10 minutes. The reaction mixture was stirred for 1 hour then diluted with 15 ml of ethyl acetate. The resulting slurry was filtered and the filtrate concentrated in vacuo to give a solid. Recrystallization (EtOAc/petroleum ether) of the solid afforded 1.45 g (77%) of title compound as white crystals, m.p. 130°-134°.

Provenance & Evidence