HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine hydrate (1:1) → 1,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-aminoethoxy)carbonyl-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine hydrate (1:1) | HCID 24654 | — |
| Reactant | 1,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine | HCID 14011675 | — |
| Solvent | tert-Butyl methyl ether | HCID 15413 | — |
| Product | 1,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-aminoethoxy)carbonyl-pyridine | HCID 14011679 | 51% |
Reaction Steps
Prepared by a method analogous to that of Example 1(b) from 10.0 g (19 mmol) of 1,4-dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine and 2.84 ml (57 mmol) of hydrazine hydrate. 3.85 g (51%) of pale yellow crystals melting at 166°-167° C. obtained from tert.-butylmethyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04757080 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-43ac57270ae34c909a973a788eda284c |
| Source note | uspto-grants-1988_07 |