Methyl 3-aminocrotonate → HCID 14011676, compound

Participants

Reaction Steps

Prepared by a method analogous to that of Example 7(a) from 23.0 g (50 mmol) of 2-(2-nitrobenzylidene)-aceto acetic acid-(6-phthalimidohexyl)ester and 5.7 g (50 mmol) of 3-amino-crotonic acid methyl ester. 9.7 g (35%) of a dark yellow oil obtained after column chromatographic purification on silica gel with dichloromethane/methanol (98:2) as solvent.

Provenance & Evidence