N-Methylpiperidine → HCID 14208556, compound

Participants

Reaction Conditions

Reaction Steps

The title product of Example 2 (7.4 g, 17.9 mmol) dissolved in 75 ml of CH2Cl2 was flushed with Ar and cooled to 0° C. N-methylpiperidine (NMP, 2.2 ml, 17.9 mmol) was added to the reaction before it was cooled to -78° C. and charged with 2.5 ml (17.9 mmol) of IBCF. The reaction was allowed to warm to -15°, maintained at this temperature for 15 min., cooled to -78°, and charged with 2.4 g (17.9 mmol) of 3 phenylpropyl amine (PPA). The crude product, obtained after a reaction work up by the method of Example 1, was chromatographed on a Waters prep 500 using a Porasil cartridge eluting with 2% to 3% ethanol (EtOH)/CH2Cl2. The title product was obtained as a white solid (4.54 g).

Provenance & Evidence