L-Leucine → HCID 86748591, compound

HRID 845360Notes

Reaction equation

HRID 845360 reaction equation
[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].O.O.C([O-])(=O)C.[Zn+2:16].C([O-])(=O)C>O>[NH2:1][C@H:2]([C:7]([OH:9])=[O:8])[CH2:3][CH:4]([CH3:6])[CH3:5].[Zn:16]

Participants

4

Reactant 2

HCID 6106L-LeucineHCID 2724192Zinc acetate (USP)

Product 1

HCID 86748591HCID 86748591, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent3×

Conditions

Temperature
120 fahrenheit

Procedure

Anhydrous L-leucine, 5.2472 g, 0.0400 mole, was dissolved in 30 ml of deionized water and heated to 120° F. Ultra-pure zinc acetate dihydrate, Zn(C2H3O2)2.2H2O, 4.3900 g, 0.0200 mole, was added in small increments over one hour, with stirring. The solution did not clear, so another 20 ml of water was added and the mixture was heated in a boiling water bath to 190° F. for an additional 21/2hours. Water was then added to a total volume of 75 ml, the mixture heated again to 190° F., and gravity filtered. The retained solid was dried at 150° F. for 12 hours, found to weigh 2.717 g, and was analyzed.

Workup

  1. temperaturethe mixture was heated in a boiling water bath to 190° F. for an additional 21/2hours
  2. temperaturethe mixture heated again to 190° F.
  3. filtrationgravity filtered
  4. customThe retained solid was dried at 150° F. for 12 hours

Sources & evidence

ORD record
ord-1ab44435ff0042c78c6f1c8a87b803e8
Source dataset
uspto-grants-1988_07
Patent number
US04758439

Reaction notes

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