HuagongsheHuagongshe Chemistry Print Report · For research reference only
Benzoate → 2-(4-Chloro-3-nitrophenylcarboxy)ethyl 3,5-di-t-butyl-4-hydroxybenzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Benzoate | HCID 242 | — |
| Reactant | 3,5-Di-tert-butyl-4-hydroxybenzoyl chloride | HCID 3787187 | — |
| Reactant | 4-Chloro-3-nitrophenyl 3,5-di-t-butyl-4-hydroxybenzoate | HCID 20131013 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 2-(4-Chloro-3-nitrophenylcarboxy)ethyl 3,5-di-t-butyl-4-hydroxybenzoate | HCID 20131005 | 86% |
Reaction Steps
A solution of the benzoate (13.7 g, 55.9 mmole) from (a) and 3,5-di-t-butyl-4-hydroxybenzoyl chloride (15.0 g, 55.9 mmole) in dichloromethane (50 ml) were heated under reflux for 42 hours. The solvent was removed by rotary evaporation, and the residue crystallized from 10% toluene in hexane, to give the product (22.9 g, 86%) as a white solid. m.p. 106°-108° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04758501 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-fa7b7142c1844d36b5313aa177ac3e16 |
| Source note | uspto-grants-1988_07 |