Hydrogen Bromide → HCID 131715632, compound

Participants

Reaction Steps

70 ml of a 4N solution of hydrogen bromide in glacial acetic acid are added to a solution containing 7.6 g (14.6 mmoles) of Z-Leu-Gln-Pro-NHEt in 50 ml of glacial acetic acid, then the mixture is left to stand at room temperature for 90 minutes. The mixture is slowly poured into 800 ml of ice-cold ether while stirring. After 30 minutes, the stirring is stopped and the settled precipitate is filtered and dried in a desiccator over phosphorus pentoxide to give 7.9 g of the aimed product, m.p.: 147° C.

Provenance & Evidence