Potassium Carbonate → HCID 3082690, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 1,4,5,6-tetrahydro-5,5-dimethyl-2-phenylmethylpyrimidine (1.69, 8 mmol), 1-fluoro-2-nitro-4-trifluoromethylbenzene (1.679, 8 mmol) and potassium carbonate (550 mg, 4 mmol) in acetonitrile (25 ml) was heated overnight at 40° C. The solvent was removed in vacuo and the resulting yellow solid recrystallised from ethyl acetate to yield 2,3-dihydro-2,2-dimethyl-5-phenyl-8-trifluoromethyl-1H-pyrimido[1,2-a]quinoxaline 6-oxide (800 mg) as a yellow crystalline solid, m.p. 225°-227° C. (Found: C, 64.42, H, 4.95, N, 11.23%; C20H18F3N3O requires C, 64.34, H, 4.86, N, 11.25%) and represented by the structural formula: ##STR6##

Provenance & Evidence