Iodoethanol → HCID 20131060, compound

HRID 845387Notes

Reaction equation

HRID 845387 reaction equation
[C:1]([S:9][C:10]1[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[I:16][CH2:17][CH2:18][OH:19]>CC(C)=O>[I-:16].[OH:19][CH:18]([N+:12]1[CH:13]=[CH:14][CH:15]=[C:10]([S:9][C:1](=[O:8])[C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:11]=1)[CH3:17]

Participants

4

Reactant 2

HCID 12225IodoethanolHCID 11958306HCID 11958306, compound

Product 1

HCID 20131060HCID 20131060, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

5.3 g of 3-benzoylthiopyridine was dissolved in 30 ml of acetone, and 9.4 ml of 2-iodoethanol was added thereto and reacted for 16 hours, while heated under reflux. After the reaction, the reaction solution was concentrated and the remaining residue was washed with ether and then with a mixture solution of methylene chloride/ether (=2/1) and dried to obtain 5.3 g of 1-hydroxyethyl-3-benzoylthiopyridinium iodide.

Workup

  1. customreacted for 16 hours
  2. temperaturewhile heated
  3. temperatureunder reflux
  4. customAfter the reaction
  5. concentrationthe reaction solution was concentrated
  6. washthe remaining residue was washed with ether
  7. dry with materialwith a mixture solution of methylene chloride/ether (=2/1) and dried

Sources & evidence

ORD record
ord-465b08a02aad4d66892e21472223bf2d
Source dataset
uspto-grants-1988_07
Patent number
US04758557

Reaction notes

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