3,5-Dichlorobenzoic acid → HCID 178478547, compound

HRID 845408Notes

Reaction equation

HRID 845408 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[C:9]([Cl:11])[CH:10]=1)[C:5](O)=O.[NH2:12][C:13]1[CH:14]=[N:15][CH:16]=[CH:17][C:18]=1[NH2:19]>>[ClH:1].[Cl:1][C:2]1[CH:3]=[C:4]([C:5]2[NH:19][C:18]3[CH:17]=[CH:16][N:15]=[CH:14][C:13]=3[N:12]=2)[CH:8]=[C:9]([Cl:11])[CH:10]=1

Participants

3

Reactant 2

HCID 58113,5-Dichlorobenzoic acidHCID 59183,4-Diaminopyridine

Product 1

HCID 178478547HCID 178478547, compound

Procedure

When 3,5-dichlorobenzoic acid and 3,4-diaminopyridine were reacted according to the procedure in Example 1, the title compound (base) was obtained. Upon converting to the hydrochloride salt and crystallization from ethanol/dimethylformamide/water, a 61% yield of pure 2-(3,5-dichlorophenyl)imidazo[4,5-c]pyridine hydrochloride was obtained as cream-colored needles, m.p. >320° C.

Sources & evidence

ORD record
ord-11514e9cbdae4f2aac7c8e21baf38808
Source dataset
uspto-grants-1988_07
Patent number
US04758574

Reaction notes

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