反应详情

A mixture of 3 g of 3-phenyl-1,2,4-thiadiazole-5-sulfonamide and and 11 ml of trimethyl orthoisobutyrate was warmed to about 90° using a oil bath. After 2.5 hours, the solution was allowed to cool to room temperature, whereupon a precipitate formed. Hexane (25 ml) was added to complete the precipitation. The solid was collected, washed with hexane and vacuum dried (P2O5) to give 3.34 g of solid, m.p. 123°-124°.

1. temperaturewas warmed to about 90°
2. customformed
3. customthe precipitation
4. customThe solid was collected
5. washwashed with hexane and vacuum
6. dry with materialdried (P2O5)