3-(8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4-isopropyl-1H-1,2,4-triazol-5(4H)-one → 2-(4-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carbonitrile

HRID 84547Notes

Reaction equation

HRID 84547 reaction equation
Br[C:2]1[CH:3]=[CH:4][C:5]2[C:11]3[S:12][C:13]([C:15]4[N:19]([CH:20]([CH3:22])[CH3:21])[C:18](=[O:23])[NH:17][N:16]=4)=[CH:14][C:10]=3[CH2:9][CH2:8][O:7][C:6]=2[CH:24]=1.[C:25]([Cu])#[N:26]>>[CH:20]([N:19]1[C:18](=[O:23])[NH:17][N:16]=[C:15]1[C:13]1[S:12][C:11]2[C:5]3[CH:4]=[CH:3][C:2]([C:25]#[N:26])=[CH:24][C:6]=3[O:7][CH2:8][CH2:9][C:10]=2[CH:14]=1)([CH3:22])[CH3:21]

Participants

3

Reactant 2

HCID 579000953-(8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4-isopropyl-1H-1,2,4-triazol-5(4H)-oneHCID 178418546HCID 178418546, compound

Product 1

HCID 579003532-(4-isopropyl-5-oxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-8-carbonitrile

Procedure

Following the procedure of Example 53, 3-(8-bromo-4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4-isopropyl-1H-1,2,4-triazol-5(4H)-one and CuCN were reacted to give 259. MS: (ESI+) 353.1

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-4b922159286f42b89e0470c181cc61e2
Source dataset
uspto-grants-2014_09
Patent number
US08846762B2

Reaction notes

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