Ammonia → HCID 86742267, compound

HRID 845492Notes

Reaction equation

HRID 845492 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[C:10](=[O:11])[CH2:9][C@@H:8]2[CH2:12][CH2:13][CH2:14][C@H:7]12)C.[NH3:16]>CO>[O:11]=[C:10]1[N:6]([CH2:5][C:4]([NH2:16])=[O:3])[C@H:7]2[CH2:14][CH2:13][CH2:12][C@H:8]2[CH2:9]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86742268HCID 86742268, compound

Product 1

HCID 86742267HCID 86742267, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A example of this step is a solution of cis-hexahydro-2-oxo-cyclopenta[b]pyrrole-1(2H)-acetic acid ethyl ester (3.25 g, 0.0154 mole) in methanol (200 ml) is saturated with anhydrous ammonia and stirred at ambient temperature 24 hours. The solution is concentrated at reduced pressure to yield a solid. Recrystallization from acetonitrile yields pure cis-hexahydro-2-oxo-cyclopenta[b]pyrrole-1(2H)acetamide with a mp 142.5°-143.5° C. ##STR4##

Workup

  1. concentrationThe solution is concentrated at reduced pressure
  2. customto yield a solid
  3. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-1851284a12144a80bff2bcac62b2c429
Source dataset
uspto-grants-1988_07
Patent number
US04758585

Reaction notes

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