HCID 56989982, compound → HCID 86742269, compound

Participants

Reaction Steps

A solution of 5-n-butyloctahydro-2-oxo-1H-indoleacetic acid ethyl ester (3aα, 7aα) (VI) (5.0 g, 0.0178 mole) in N,N-bis-(1-methylethyl)aminoethylamine (4.49 g, 0.0267 mole) is heated at 100° C. for 18 hours. The solution is concentrated at reduced pressure to an oil. The oil is dissolved in 2-propanol and the solution is treated with a saturated solution of hydrogen chloride in 2-propanol. The solution is diluted with anhydrous diethyl ether and allowed to crystallize. The crystals are filtered. Recrystalliztion from acetonitrile-diethyl ether yields pure 5-n-butyloctahydro-2-oxo-1H-indoleacetamide N-[bis[1-methylethyl]amino]ethyl]·hydrochloride (3aα, 7aα) (VII) with mp 116°-118° C.

Provenance & Evidence