Ammonia → HCID 86742267, compound

HRID 845496Notes

Reaction equation

HRID 845496 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[C:10](=[O:11])[CH2:9][C@@H:8]2[CH2:12][CH2:13][CH2:14][C@H:7]12)C.[NH3:16]>CO>[O:11]=[C:10]1[N:6]([CH2:5][C:4]([NH2:16])=[O:3])[C@H:7]2[CH2:14][CH2:13][CH2:12][C@H:8]2[CH2:9]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 86742268HCID 86742268, compound

Product 1

HCID 86742267HCID 86742267, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of cis-hexahydro-2-oxo-cyclopenta-[b]pyrrole-1(2H)-acetic acid ethyl ester (3.25 g, 0.0154 mole) in methanol (200 ml) is saturated with anhydrous ammonia and stirred at ambient temperature 24 hours. The solution is concentrated at reduced pressure to yield a solid. Recrystallization from acetonitrile yields pure cis-hexahydro-2-oxo-cyclopenta[b]pyrrole-1(2H)-acetamide with a mp 142.5°-143.5° C.

Workup

  1. concentrationThe solution is concentrated at reduced pressure
  2. customto yield a solid
  3. customRecrystallization from acetonitrile

Sources & evidence

ORD record
ord-0718d2bd69404ff88a1bb5868772785b
Source dataset
uspto-grants-1988_07
Patent number
US04758585

Reaction notes

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