Ammonia → HCID 86742273, compound

HRID 845499Notes

Reaction equation

HRID 845499 reaction equation
C([O:3][C:4](=O)[CH2:5][N:6]1[C:10](=[O:11])[CH2:9][C@@H:8]2[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][C@H:7]12)C.[NH3:18].C(OCC)C>CO>[O:11]=[C:10]1[N:6]([CH2:5][C:4]([NH2:18])=[O:3])[C@H:7]2[CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][C@H:8]2[CH2:9]1

Participants

5

Reactant 3

HCID 222AmmoniaHCID 3283Diethyl EtherHCID 86742269HCID 86742269, compound

Product 1

HCID 86742273HCID 86742273, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of cis-octahydro-2-oxo-cyclohepta[b]pyrrole-1(2H)-acetic acid ethyl ester (3.0 g, 0.0125 mole) in methanol (50 ml) is saturated with anhydrous ammonia. The solution is stirred at ambient temperature for 72 hours. the solution is concentrated at reduced pressure to yield a solid. Trituration with anhydrous diethyl ether yields pure cis-octahydro-2-oxo-cyclohepta[b]pyrrole-1(2H)acetamide with mp 140°-142° C.

Workup

  1. concentrationthe solution is concentrated at reduced pressure
  2. customto yield a solid

Sources & evidence

ORD record
ord-3f1b09ec9cda4890a8799faa86865a36
Source dataset
uspto-grants-1988_07
Patent number
US04758585

Reaction notes

Loading…