HCID 54531533, compound → HCID 54239114, compound

Participants

Reaction Steps

A mixture of 5 g (19 mmol) of 1-benzyloxy-3-(3-hydroxy-1 propen-1-yl) indole and 25 g of activated manganese dioxide in 500 ml of dichloromethane was stirred at room temperature for three hours and filtered through Celite®. The manganese compound was washed thoroughly with a mixture of dichloromethane and ethyl acetate until the Celite® layer was colorless. The combined filtrate and washing were concentrated on rotary evaporator and the residue was purified on a dry column (25% ethyl acetate in hexane) to give 2.3 g of 3-(1-benzylindol-3-yl)acrolein.

Provenance & Evidence