反应详情

温度

20 °C

1.57 g of 2-chloromethyl-4,5-dimethoxypyridinium chloride are added to a solution of 1.64 g of 2-mercapto-5-trifluoromethoxy-1H-benzimidazole in 40 ml of ethanol and 20 ml of 1N sodium hydroxide solution, the mixture is stirred at 20° C. for 2 hours and then at 40° C. for a further hour, the ethanol is distilled off on a rotary evaporator (10 mbar/40° C.) and the colorless precipitate which thereby separates out is filtered off over a suction filter, rinsed with 1N sodium hydroxide solution and water and dried. 2.15 g (79% of theory) of the title compound of m.p. 92°-93° C. are obtained.

1. waitat 40° C. for a further hour
2. distillationthe ethanol is distilled off on a rotary evaporator (10 mbar/40° C.)
3. filtrationthe colorless precipitate which thereby separates out is filtered off over a suction
4. filtrationfilter
5. washrinsed with 1N sodium hydroxide solution and water
6. customdried