1H-1,2,4-Triazole → HCID 13021647, compound

Participants

Reaction Steps

63.0 g of 1-bromo-1-fluoro-3,3-dimethyl-2-butanone are added slowly to a mixture of 23.0 g of 1,2,4-triazole and 44.2 g of potassium carbonate in 280 ml of ethyl methyl ketone. The reaction mixture is stirred for 18 hours at 45°-50° C. and is then filtered and evaporated. The residue is taken up in methylene chloride and washed with water. Drying and evaporating the organic phase gives 50.0 g of 1-fluoro-1-(1H-1,2,4-triazol-1-yl)-3,3-dimethyl-2-butanone, melting point 54°-55° C.

Provenance & Evidence