Tetrahydrofuran → HCID 20131574, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 20 g of 1-fluoro-1-(1H-1,2,4-triazol-1-yl)-3,3-dimethyl-2-butanone, 13.5 g of potassium tertiary butylate, 24.0 g of trimethylsulfoxonium iodide, 80 ml of tetrahydrofuran and 20 ml of dimethyl sulfoxide is stirred at 60° C. for 6 hours. The reaction mixture is then taken up in ice water and extracted with ethyl acetate. The combined organic phases are washed with water and saturated sodium chloride solution, dried over sodium sulfate and evaporated. Crystallisation from petroleum ether gives 6.9 g of 2-tert.-butyl-2-[(1H-1,2,4-triazol-1-yl)-fluoromethyl]-oxirane, melting point 72°-74° C.

Provenance & Evidence