Dimethyl Sulfoxide → HCID 20131577, compound

Participants

Reaction Conditions

Reaction Steps

12.0 g of 2-fluoro-2-(1H-1,2,4-triazol-1-yl)-4,4-dimethyl-3-pentanone are added dropwise to a mixture of 13.2 g of trimethylsulfoxonium iodide, 7.3 g of potassium tertiary butylate, 20 ml of dimethyl sulfoxide and 80 ml of tetrahydrofuran, and the reaction mixture is stirred for 18 hours at 80° C. After cooling, the mixture is taken up in ice water and extracted with ethyl acetate. The combined organic phases are washed with water and saturated sodium chloride solution, dried over sodium sulfate and evaporated. Distillation of the oily residue gives 6 g 2-tert.-butyl-2-[1-fluoro-1-(1H-1,2,4-triazol-1-yl)-ethyl]-oxirane, boiling point 60°-61° C./0.013 mbar.

Provenance & Evidence