HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isopropanol → Isopropyl acetoacetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isopropanol | HCID 3776 | — |
| Reactant | 2,2,6-Trimethyl-4H-1,3-dioxin-4-one | HCID 79368 | — |
| Solvent | Acetone | HCID 180 | — |
| Product | Isopropyl acetoacetate | HCID 68329 | 90.2% |
Reaction Steps
A solution of 2,2,6-trimethyl-4H-1,3-dioxin-4-one (53)70 (74 g, 0.5 mol) and 2-propanol (30 g, 0.5 mol) was heated at 135° C. for 20 h. The acetone formed during the reaction was removed with a rotary evaporator. The residue was distilled to provide 65 g (0.451 mol, 90%) of 54 as a clear, colorless liquid: bp 185°-187° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04758669 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-0080dd0dc40f4fbd8b09a373bd10b88e |
| Source note | uspto-grants-1988_07 |