反应详情

To a solution of 3-nitrobenzyl alcohol (90) (1.53 g, 10 mmol) and NH4Cl (1.3 g, 24.3 mmol) in 86% aqueous ethanol (88 mL) was added zinc powder (2.6 g, 39.8 mmol). The resulting mixture was stirred vigorously at room temperature for 50 min. The mixture was filtered, and the solvent was poured into dichloromethane (450 mL). The solution was washed with water (10 mL) and dried (MgSO4), and the solvent was concentrated to about 15 mL with a rotary evaporator. The resulting solution was used in subsequent reactions without further purifications.

1. filtrationThe mixture was filtered
2. additionthe solvent was poured into dichloromethane (450 mL)
3. washThe solution was washed with water (10 mL)
4. dry with materialdried (MgSO4)
5. concentrationthe solvent was concentrated to about 15 mL with a rotary evaporator