Hydrochloric Acid → HCID 131715641, compound

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Reaction Steps

13.6 g of Boc-Ser-Asn-Leu-Ser-NHNH2 are dissolved in 150 ml of dimethylformamide, cooled to -20°, then 40 ml of an anhydrous solution of HCl (2N) in dioxane are added, followed by 3.6 ml of tert.-butylnitrite. After 10 minutes at -20°, 16 ml of triethylamine and 13.0 g of H-Thr-Cys(Acm)-Val-Leu-OH are added, and the solution stirred for 16 hours at 25°. The mixture is filtered, the filtrate is evaporated to dryness, the residue is suspended repeatedly in 1N acetic acid and in water, filtered and dried to give the title compound.

Provenance & Evidence