HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diazomethane → HCID 70377919, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diazomethane | HCID 9550 | — |
| Reactant | HCID 131715644 | HCID 131715644 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 70377919 | HCID 70377919 | — |
Reaction Steps
The Boc-benzyl ester (J) (4 mmol) is dissolved in methylene chloride and treated with excess ethereal diazomethane at room temperature. The residual diazomethane is quenched with acetic acid and the solution is evaporated at reduced pressure. The crude diester is dissolved in methanol and hydrogenated over 10% palladium-on-carbon to give, after flash chromatography (silica gel), the titled compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04760052 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-07c7d16b8b3945cebd09dd249b6fcb60 |
| Source note | uspto-grants-1988_07 |