Acetonitrile → HCID 13604883, compound

HRID 845741Notes

Reaction equation

HRID 845741 reaction equation
CS(O[C:6]1[C:7](C)=[N:8][CH:9]=[C:10]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:11]=1)(=O)=O.[C:19]1([C:25]2[CH2:26][CH2:27][NH:28][CH2:29][CH:30]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1.[C:31](#N)C>>[C:19]1([C:25]2[CH2:30][CH2:29][N:28]([CH2:31][C:6]3[CH:7]=[N:8][CH:9]=[C:10]([C:12]4[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=4)[CH:11]=3)[CH2:27][CH:26]=2)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 3

HCID 6342AcetonitrileHCID 825531,2,3,6-Tetrahydro-4-phenylpyridineHCID 20130371HCID 20130371, compound

Product 1

HCID 13604883HCID 13604883, compound

Procedure

A solution of 26.3 g of 3-methylsulfonyloxy-methyl-5-phenyl-pyridine (obtainable by reduction of 5-phenyl- pyridine-3-carboxylic acid with LiAlH4 to give 3-hydroxy- methyl-5-phenyl-pyridine and mesylation) and 16 g of 4- phenyl-1,2,3,6-tetrahydropyridine in 100 ml of acetonitrile is stirred at 20° for 12 hours and worked up in the customary manner to give 3-(4-phenyl-1,2,3,6 -tetrahydropyridyl-methyl)-5-phenyl-pyridine ("P"), melting point: 80°-82°. Dihydrochloride, melting point: 218°-220°.

Sources & evidence

ORD record
ord-b43ed37ab26b4c5886c50ee9e72ca7ca
Source dataset
uspto-grants-1988_07
Patent number
US04760082

Reaction notes

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