反应详情

1-(4-Hydroxybenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihyrocarbostyril (9 g) was suspended in DMF (90 ml). To the suspension were added potassium carbonate (2.82 g) and benzyl monochloroacetate (3.81 g) and the mixture was stirred at room temperature over night. After completion of reaction, the reaciton mixture was poured into water and extracted with dichloromethane. The extract was washed successively with water and saturated saline solution, dried over magnesium sulfate and evaporated under reduced pressure. The residue was purified by silica-gel column chromatography [eluent:dichloromethane:methanol=100:0 to 100:5] to give 1-(4-benzyloxycarbonylmethoxybenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydroxycarbostyril (4.0 g).

1. customAfter completion of reaction
2. extractionextracted with dichloromethane
3. washThe extract was washed successively with water and saturated saline solution
4. dry with materialdried over magnesium sulfate
5. customevaporated under reduced pressure
6. customThe residue was purified by silica-gel column chromatography [eluent:dichloromethane:methanol=100:0 to 100:5]