HCID 20130164, compound → HCID 20130171, compound

Participants

Reaction Steps

To a solution of 1-(4-benzyloxycarbonylmethoxybenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (4 g) in a mixture of DMF (30 ml) and ethanol (30 ml) was added 10% palladium on carbon (500 mg) and the mixture was hydrogenated at room temperature and atmospheric pressure. After completion of reaction, the catalyst was filtered off and the filtrate was evaporated under reduced pressure. The residue was dissolved in dichloromethane. The solution was washed with water, dried and evaporated under reduced pressure. The resultant residue was purified by silica-gel column chromatography (eluent:dichloromethane:methanol=100:2 to 1:1) to give 1-(4-carboxymethoxybenzoyl)-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl]-3,4-dihydrocarbostyril (3.1 g).

Provenance & Evidence