Sodium Hydroxide → 4-(2-Hydroxyethanesulfonyl)-2-nitrophenol

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Reaction Steps

The synthesis of 2-amino-4-(beta-sulfatoethylsulfonyl)-phenol is somewhat difficult in that it requires several reaction steps involving a high investment for equipment. In its preparation, it is necessary to start from 2-nitro-4-(beta-hydroxyethylsulfonyl)-anisole which is dealkylated by heating with aqueous sodium hydroxide solution to give 2-nitro-4-(beta-hydroxyethylsulfonyl)-phenol. The resulting phenol is then reduced to give 2-amino-4-(beta-hydroxyethyl-sulfonyl)-phenol which, in turn, must be sulfated in accordance with the disclosure of U.S. Pat. Nos. 3,364,194 or 4,334,076.

Provenance & Evidence