反应详情

One g of platinum oxide was added to 100 ml of ethanol, and hydrogen was passed through the solution under stirring for 30 minutes. To this solution was added a solution of 54.06 g (0.3 mol) of 2-methoxy-3,4-methylenedioxybenzaldehyde (1) and 40.78 g (0.3 mol) of aminoacetaldehyde diethylacetal (2) (purity: 98%) in 100 ml of ethanol to carry out hydrogenation under stirring at room temperature for 8.5 hours. Then the catalyst was filtered out and the solvent was distilled off under reduced pressure to obtain 89.43 g of N-(2-methoxy-3,4-methylenedioxybenzyl)aminoacetaldehyde diethylacetal (2) as an oil (yield: 100%).

1. stirringunder stirring at room temperature for 8.5 hours
2. filtrationThen the catalyst was filtered out
3. distillationthe solvent was distilled off under reduced pressure