Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Diethyl Ether | HCID 3283 | — |
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Anisole | HCID 7519 | — |
| Reactant | HCID 86742288 | HCID 86742288 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 54551191 | HCID 54551191 | 75.1% |
Reaction Steps
A mixture of 255 mg of (6R-trans)-3-[(acetyloxy)methyl]-7-[(5-acetyl-2-thiazolyl)amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, diphenylmethyl ester was reacted with anisole and trifluoroacetic acid in dichloromethane with stirring at 0° C. for 30 minutes, then at room temperature for 30 minutes. The addition of ether and petroleum ether gave a precipitate which was washed with ether, giving 135 mg of the desired product as a pale yellow powder.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US04760140 |
|---|
| Source dataset | uspto-grants-1988_07 |
|---|
| ORD ID | ord-13138c7cb69b4acf8f9e6fec552eb7e5 |
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| Source note | uspto-grants-1988_07 |
|---|
