HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Cyanide → 2-Fluoro-5-hydroxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Cyanide | HCID 9032 | — |
| Reactant | 4,4-Difluorocyclohexa-2,5-dien-1-one | HCID 14274451 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 2-Fluoro-5-hydroxybenzonitrile | HCID 22612410 | 90% |
Reaction Steps
When 2 mmol of 4,4-difluorocyclohexadienone and 4 mmol of potassium cyanide in 0.5 ml of dimethylformamide were mixed for 10 minutes at room temperature, 3-cyano-4-fluorophenol was formed in 90% yield. The spectral data of this new compound are as follows: Mass spectrum: m/e 137 (M+); 109 (M-CO, H); 82; 57.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04760160 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-d5ccff0370f04f7ab58656308b2d55c6 |
| Source note | uspto-grants-1988_07 |