Dimethylamine → 3-(Dimethylamino)-2-methylpropanoic acid
Reaction equation
[C:1](OC)(=O)[CH2:2][C:3]([O-:5])=[O:4].[CH3:9][NH:10][CH3:11].[CH2:12]=O>O>[CH3:9][N:10]([CH3:12])[CH2:11][CH:2]([CH3:1])[C:3]([OH:5])=[O:4]Participants
5
Reactant 3
Product 1
Reagents, catalysts & solvents 1
Conditions
- Temperature
- 0 °C
Procedure
In 1.0 ml of water was dissolved 1.5 g of methyl malonate, after which 1.26 g of a 50% aqueous dimethylamine solution and 0.96 ml of a 37% aqueous formaldehyde solution were added with stirring at 0° C., and the resulting mixture was stirred at 0° to 5° C. for 3 hours and then at 80° C. for 30 minutes.
Workup
- stirringthe resulting mixture was stirred at 0° to 5° C. for 3 hours
Sources & evidence
- ORD record
- ord-9b1b01a9eb5b4b22b82234cb3d9834dc
- Source dataset
- uspto-grants-1988_07
- Patent number
- US04760136
Reaction notes
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